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Mesut Işık Selected Research

Alzheimer Disease (Alzheimer's Disease)

3/2024Explainable artificial intelligence in the design of selective carbonic anhydrase I-II inhibitors via molecular fingerprinting.
11/2023Evaluation of the relationship among gene expressions and enzyme activities with antioxidant role and presenilin 1 expression in Alzheimer's disease.
8/2023Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors.
4/2022AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress.
1/2022Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors.
10/2021The impact of some phenolic compounds on serum acetylcholinesterase: kinetic analysis of an enzyme/inhibitor interaction and molecular docking study.
4/2021Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α-Glycosidase and Cholinesterase Inhibitors.
9/2019The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking.

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Mesut Işık Research Topics

Disease

8Alzheimer Disease (Alzheimer's Disease)
03/2024 - 09/2019
2Glaucoma
03/2024 - 08/2023
2Epilepsy (Aura)
08/2023 - 01/2015
2Coronary Artery Disease (Coronary Atherosclerosis)
04/2022 - 01/2022
2Diabetes Mellitus
01/2022 - 04/2021
1Parkinson Disease (Parkinson's Disease)
08/2023
1COVID-19
05/2023
1Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
05/2022
1Metabolic Diseases (Metabolic Disease)
01/2022
1Atherosclerosis
01/2022
1Cerebrovascular Disorders (Cerebrovascular Occlusion)
01/2022
1Cardiovascular Diseases (Cardiovascular Disease)
10/2021
1Neurodegenerative Diseases (Neurodegenerative Disease)
12/2020
1Inflammation (Inflammations)
08/2020
1Hyperglycemia
09/2017
1Ischemia
03/2017
1Stroke (Strokes)
03/2017

Drug/Important Bio-Agent (IBA)

7EnzymesIBA
03/2024 - 09/2017
5AcetylcholinesteraseIBA
08/2023 - 03/2017
4AntioxidantsIBA
11/2023 - 01/2015
3Biomarkers (Surrogate Marker)IBA
04/2022 - 10/2021
2Carbonic Anhydrases (Carbonic Anhydrase)IBA
08/2023 - 08/2023
2Messenger RNA (mRNA)IBA
04/2022 - 01/2022
2ButyrylcholinesteraseIBA
01/2022 - 04/2021
2Cholinesterases (Cholinesterase)IBA
01/2022 - 01/2015
2Free RadicalsIBA
10/2021 - 03/2017
1Carbonic Anhydrase IIBA
03/2024
1Carbonic Anhydrase IIIBA
03/2024
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2023
1Presenilin-1IBA
11/2023
1SulfonamidesIBA
08/2023
1fibrin fragment D (D-dimer)IBA
05/2023
1TroponinIBA
05/2023
1DisulfidesIBA
05/2022
1Sulfhydryl Compounds (Thiols)IBA
05/2022
12-(N-cyclohexylamino)ethanesulfonic acid (CHES)IBA
01/2022
1GlucosidasesIBA
01/2022
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
10/2021
1Cholinesterase Inhibitors (Anticholinesterases)IBA
10/2021
1Acetylcholine (Acetylcholine Chloride)FDA Link
10/2021
1SulfaguanidineIBA
04/2021
1Glycoside Hydrolases (Endoglycosidases)IBA
04/2021
1PhytochemicalsIBA
08/2020
1Amyloid (Amyloid Fibrils)IBA
09/2019
1Sorbitol (Yal)FDA Link
09/2017
1Aldehyde Reductase (Aldose Reductase)IBA
09/2017
1polyolIBA
09/2017
1Glutathione (Reduced Glutathione)IBA
01/2015
1Aryldialkylphosphatase (Paraoxonase)IBA
01/2015
1Glutathione Transferase (Glutathione S-Transferase)IBA
01/2015